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藥用高分子(英文版)
 作  者: 王者輝
 出版單位: 化學工業
 出版日期: 2018.10
 進貨日期: 2018/11/9
 ISBN: 9787122324832
 開  本: 16 開    
 定  價: 660
 售  價: 528
  會 員 價 : 484

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一本系統講述藥用高分子材料的書籍,帶你放眼閱讀高分子材料在醫藥學方向的應用。


內容簡介:

《Pharmaceutical Polymers(藥用高分子)》基於現代藥劑學的發展,依據國內外第一資料,結合作者多年來的教學科研實踐編寫而成,系統講述了高分子在藥物製劑中的應用。全書共分為十章,具體內容包括:藥用高分子化學基礎理論(第一章);藥用高分子的原理與結構(第二章);天然來源與合成藥用高分子(第三章);天然來源高分子在藥學領域的應用(第四章);疏水性高分子聚合物的藥用價值(第五章);高分子聚合物在藥物傳遞中的應用(第六章);醫藥納米技術(第七章);藥用高分子的熱分析(第八章);原子力顯微鏡在藥用高分子中的應用(第九章);藥物高分子的流變學研究(第十章)。《Pharmaceutical Polymers(藥用高分子)》可供普通高等醫藥院校藥學、藥物製劑、制藥工程、高分子材料與工程等相關專業學生及從事藥物製劑生產、研究的人員參考使用。


作者簡介:

王者輝,泰山醫學院,副教授, 自2004年以來,長期從事高分子材料專業的本、專科的教學,教授的課程主要有材料導論、專業英語、聚合物改性、塗料化學、光化學與光物理、波譜分析、聚合物加工流變學、高分子材料概論等。科研方向為醫用高分子材料、高分子介面。


圖書目錄:

Chapter 1 Fundamentals of Pharmaceutical Polymer Chemistry 1

1.1 The Concept of a Polymer 1

1.2 Addition Polymerization 4

1.3 Chain Branching; Graft and BlockCopolymers 15

1.4 Polymer Structure and Properties 18

1.5 Technology of Polymerization 24

1.6 The Principal Monomers and TheirPolymers 27

1.7 Physical Properties of Monomers 37

References 41

Chapter 2 Pharmaceutical Polymers:Principles and Structures 42

2.1 Introduction 42

2.2 Intra and Inter Polymer MolecularInteractions 45

2.3 Molecular Mass: Polydispersivity andEffects on Polymer Viscosity 47

2.4 Thermal Properties: Effect ofCrystalline and Amorphous Phases 51

2.5 Mechanical Properties of Polymers 54

2.6 Pharmaceutical Polymers: Principles,Structures, and Applications of Pharmaceutical Delivery Systems 61

References 80

Chapter 3 Polymers as Drugs 81

3.1 Introduction 81

3.2 Polymers for Molecular Sequestration83

3.3 Polyvalent Interactions andAnti-Infective Polymeric Drugs 95

3.4 Polymeric Drugs for the Treatment ofAutoimmune Diseases 105

3.5 Polymeric Anti-Obesity Drugs 107

3.6 Polymer Therapy for Sickle CellDisease 111

3.7 Conclusions and Outlook on Polymersas Drugs 112

References 113

Chapter 4 Pharmaceutical Applications ofNatural Polymers 114

4.1 Introduction 114

4.2 Portals of Drug Administration inthe Human Body 116

4.3 Transdermal Drug Delivery Devices117

4.4 Topical Drug Delivery 124

4.5 Oral Drug Delivery System 131

4.6 Parenteral Drug Delivery Systems 132

4.7 Nasal Drug Delivery Systems 134

4.8 Hydrogel-Based Drug Delivery Systems136

References 147

Chapter 5 Hydrophobic Polymers ofPharmaceutical Significance 149

5.1 Introduction 149

5.2 Examples of Hydrophobic Polymers andTheir Drug Delivery Applications 150

5.3 Conclusions 167

References 168

Chapter 6 Polymers in Drug Delivery 169

6.1 Evolution of Drug Dosage Forms 169

6.2 Polymer Excipients 172

6.3 Polymers as Manufacture Aids andSustained Release 174

References 200

Chapter 7 Pharmaceutical Nanotechnology:Overcoming Drug Delivery Challenges in Contemporary Medicine 202

7.1 Challenges in Delivery ofContemporary Therapeutics 202

7.2 Nanotechnology Solutions 207

7.3 Illustrative Examples ofNanotechnology Products 211

7.4 Multifunctional Nanotechnology 218

7.5 Regulatory Issues inNano-pharmaceuticals 225

7.6 Conclusions and Future Outlook 235

References 235

Chapter 8 Thermal Analysis ofPharmaceutical Polymers 237

8.1 Introduction 237

8.2 Theoretical Background of ThermalAnalysis 238

8.3 Physical and Chemical PhenomenaCommonly Investigated Using Thermal Approaches 244

8.4 Applications of Thermal Analysis forthe Characterisation of Pharmaceutical Raw Materials 248

8.5 Applications of Thermal Analysis forthe Characterisation of Pharmaceutical Dosage Forms 250

8.6 Conclusion 255

References 255

Chapter 9 Applications of AFM inPharmaceutical Polymers 256

9.1 Introduction 256

9.2 Use of AFM in PharmaceuticalSciences 263

9.3 AFM Combined With Optical orSpectroscopic Techniques 271

9.4 Summary 271

References 273

Chapter 10 Rheology in PharmaceuticallyUsed Polymers 274

10.1 Introduction 274

10.2 Theoretical Background andFundamental Concepts 275

10.3 Practical Issues of RheologicalMeasurements 289

10.4 Application of the Technique 292

10.5 Summary 297

References 297


章節試讀:

前言藥用高分子(Pharmaceutical polymers)是具有生物相容性、經過安全評價且應用於藥物製劑的一類高分子量藥用輔料。藥用高分子作為藥物緩釋載體,包覆在藥物表面保護小分子藥物使其在短時間內不會被生命體吸收,同時隨血液流動到特定區域,在特定區域藥物表面的高分子材料溶解到血液中,釋放出藥物,而本身最終隨體液排出。藥用高分子的主要應用有:?載體,用以控制藥物緩慢釋放,一般由有機矽橡膠、聚甲基丙烯酸酯類等製成封閉細管、微囊或薄膜。?主藥,有長效的特點,其結構有三類:(a)在高分子側基上連接小分子藥物,這類結構最受重視,即高分子親和藥物,在高分子側鏈上除含有藥物結構外,在較遠端側鏈上還含有親水結構、配基或?,以提高藥用高分子在體內分佈的專一性;(b)在高分子主鏈中含小分子藥物;(c)高分子中不含小分子藥物,其本身可作為藥物或功能試劑。本書結合現代藥劑學的發展以及作者多年來的教學科研實踐,根據國內外最新資料,簡述了有關高分子化學和物理的基本內容,概述了與藥劑學相關的高分子材料基本知識,重點介紹國際上經法定程式驗證及實際生產中已被採用的藥用高分子材料的原理和應用,充實了國外近年來備受矚目的給藥系統用天然來源藥用高分子及可生物降解的合成藥用高分子和複合物的有關內容,此外,還對熱分析、原子力顯微鏡和流變學在藥用高分子領域中的應用進行了闡述。本書可供普通高等醫藥院校藥學、藥物製劑、制藥工程、高分子材料與工程等相關專業學生及從事藥物製劑生產、研究的人員參考使用。全書共分為十章,參與本書編寫的人員及具體編寫分工如下:第一章由孫紅、王者輝編寫;第二章由張宏志、孫立平編寫;第三章由鞏學勇、劉鳳霞編寫;第四章由李慶傑、常海濤編寫;第五章由鄭超、張倩編寫;第六章由劉光耀、江棟編寫;第七章由衛振華、劉愛軍編寫;第八章由王者輝、李寶慶編寫;第九章由杜江山、劉振亮編寫;第十章由薑洪麗、孟憲鋒編寫;全書由王者輝統一整理並任主編。由於水準所限,書中不足之處在所難免,誠懇希望廣大讀者加以批評指正。編 者2018年5月PrefacePharmaceutical polymers (both synthetic and natural-based polymers) have found their way into the pharmaceutical industries and their applications are growing at a fast pace. The desirable polymer properties in pharmaceutical applications are film forming (coating), thickening (rheological modifier), gelling (controlled release), adhesion (binding), pH-dependent solubility (controlled release), solubility in organic solvents (taste masking), and barrier properties (protection and packaging). Major applications of polymers in current pharmaceutical field are for controlled drug release. From the solubility point of view, pharmaceutical polymers can be classified as water-soluble and water-insoluble (oil soluble or organic soluble). Many water-soluble pharmaceutical polymers including polyethylene glycol, polyvinyl alcohol, polyethylene oxide, polyvinyl pyrrolidone, polyacrylate or polymethacrylate esters, cellulose based polymers, hydrocolloids, and many plastics and rubbers will be tabulated and their anionic and cationic functionalities are summarized and discussed. PEGylation is defined as the covalent attachment of poly ethylene glycol (PEG) chains to bioactive substances. Pharmaceutical polymer, a kind of macromolecular compound with bioco- mpatibility, safety evaluation, is used as a kind of high molecular mass pharma- ceutical excipients for drug preparation. As a sustained release drug carrier, the pharmaceutical polymer is coated on the surface of the drug to protect small molecular weight drugs not to be absorbed by the living body in a short time. At the same time, with the flow of blood in a specific area, the polymer materials on the specific area of the drug dissolve into the blood and release the drug, and the drug itself is eventually discharged with the body fluid. The main applications of pharmaceutical polymers include: (1) the carrier, which is used to control the slow release of drugs, usually made of organosilicon rubber, polymethacrylate and others in the form of closed tubes, microcapsules or films. (2) the main drug with characteristic long time efficacy has three kinds of structures: (i) polymeric affinity drug, with the hydrophilic groups, the ligands or enzymes on the far end of the chain, have small molecular drugs connecting on the side of the polymer chains, which is the most important structure with pharmaceutical polymer uniform distribution inside the body; (ii) polymeric drug contains small molecule drugs in the main chain; (iii) polymers do not contain small molecular drugs, it act as medicine or functional reagent. This book, combined with the development of modern pharmaceutics and many years practice of teaching and scientific research, briefly describes the founda- mentals of polymer chemistry and physics, and summarizes the basic knowledge of polymers related to pharmaceutics. According to the latest information at home and abroad, this book mainly introduces the principles and applications of pharma- ceutical polymers that have been used in international legal procedure verification and actual production, and enriches the related contents of natural sources of pharmaceutical polymers and biodegradable synthetic pharmaceutical polymers and complexes in recent years. The applications of thermal analysis, atomic force microscopy and rheology in the field of pharmaceutical polymers are included. This book can be used as a reference for readers of pharmaceutical engineering, polymer materials and engineering and related majors and people engaged in the production and research of pharmaceutical preparations.The personnel involved in this book include: the first chapter by Hong Sun and Zhehui Wang; the second chapter by Hongzhi Zhang and Liping Sun; the third chapter by Xueyong Gong and Fengxia Liu; the fourth chapter by Qingjie Li and Haitao Chang; the fifth chapter by Chao Zheng and Qian Zhang; the sixth chapter by Guangyao Liu and Dong Jiang; the seventh chapter by Zhenhua Wei and Aijun Liu; the eighth chapter by Zhehui Wang and Baoqing Li; the ninth chapter by Jiangshan Du and Zhenliang Liu; the tenth chapter by Hongli Jiang and Xianfeng Meng; this whole book is edited by Zhehui Wang. As to the limitation of the authors’ level, all kinds of criticisms are welcome for various mistakes in the book, and we sincerely hope that readers will be able to inform us for correction.Zhehui Wang2018.5

 
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